Aberrations in the epidermal growth factor receptor gene in 958 patients with diverse advanced tumors: implications for therapy.

Abstract

BACKGROUND Epidermal growth factor receptor (EGFR) mutations are associated with the response to EGFR inhibitors in patients with non-small-cell lung cancer (NSCLC). We sought to investigate EGFR aberrations in patients with diverse advanced cancers. PATIENTS AND METHODS Patients referred to the phase I clinic were evaluated for the presence of EGFR mutations and response to therapy. RESULTS EGFR aberrations were detected in 34 of 958 patients (3.5%). Though EGFR mutations were most frequent in NSCLC (21 of 131, 16%), they were also present in a variety of other solid tumors (13 of 827 patients, 1.6%) including adrenocortical (1/10 patients), skin (1/24), breast (1/55), carcinoid (1/8), cholangiocarcinoma (1/20), head and neck (1/61), ovarian (1/84), parathyroid (1/1), salivary gland (1/20), renal (1/17), sarcoma (2/38), and thymic carcinomas (1/7). Of the 13 EGFR aberration-positive non-NSCLC patients (median number of prior systemic therapies = 3), 6 had treatment with an EGFR inhibitor. Two patients (diagnosis = parathyroid tumor and basal cell carcinoma) achieved stable disease (SD), lasting 6 and 7 months, respectively. CONCLUSION We found EGFR aberrations in 1.6% of a large group of patients with diverse tumors other than NSCLC, and treatment with an EGFR inhibitor could be associated with prolonged SD.

DOI: 10.1093/annonc/mds524

2 Figures and Tables

Cite this paper

@article{Wheler2013AberrationsIT, title={Aberrations in the epidermal growth factor receptor gene in 958 patients with diverse advanced tumors: implications for therapy.}, author={Jennifer J. Wheler and Gerald Steven Falchook and A M Tsimberidou and David S. Hong and Aung S. Naing and Sarina Anne Piha-Paul and Sidney S Chen and Shan Fu and B. Adolf Stephen and Jansina Y. Fok and Filip Janků and Razelle Kurzrock}, journal={Annals of oncology : official journal of the European Society for Medical Oncology}, year={2013}, volume={24 3}, pages={838-42} }