Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer

@article{Mohammad2010AberrationsIO,
  title={Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer},
  author={Naushad Shaik Mohammad and Rupasree Yedluri and Pavani Addepalli and Suryanarayana Raju Gottumukkala and Raghunadha Rao Digumarti and Vijay Kumar Kutala},
  journal={Molecular and Cellular Biochemistry},
  year={2010},
  volume={349},
  pages={159-167}
}
The authors investigated the role of dietary micronutrients and eight functional polymorphisms of one-carbon metabolism in modulating oxidative stress in sporadic breast cancer. PCR-restriction fragment length polymorphism (RFLP) and PCR-amplified fragment length polymorphism (AFLP) methods were used for genetic analysis in 222 sporadic breast cancer cases and 235 controls. Standardized food frequency questionnaire was used for dietary micronutrient assessment. 8-oxo-2′-deoxyguanosine (8-oxodG… CONTINUE READING
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