Aberration induction by mitomycin C in early primary spermatocytes of mice.

@article{Adler1976AberrationIB,
  title={Aberration induction by mitomycin C in early primary spermatocytes of mice.},
  author={I D Adler},
  journal={Mutation research},
  year={1976},
  volume={35 2},
  pages={247-56}
}
MC is well known to induce dominant lethal mutations in mouse spermatocytes. Tests were done to determine whether chromosomal aberrations could be identified in spermatocytes as being responsible for the dominant lethal effects. Male mice were treated with single doses of MC during DNA synthesis preceding meiosis and during early prophase of meiosis. Simultaneous labeling was performed to identify cells that were in S-phase during the time of treatment. Diakineses-metaphases I were analyzed for… CONTINUE READING

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