Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1.

@article{Kawano2003AberrantTO,
  title={Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1.},
  author={Hitoshi Kawano and Masao Horie and Shizuka Honma and Koki Kawamura and Kosei Takeuchi and Shioko Kimura},
  journal={Experimental neurology},
  year={2003},
  volume={182 1},
  pages={103-12}
}
In the embryonic brain, the transcription factor Nkx2.1 is localized in the medial ganglionic eminence and the ventromedial part of the hypothalamus. In the present study, we examined the development of mesencephalic dopamine (DA) neuron system in mice lacking Nkx2.1. In normal mice, tyrosine hydroxylase-immunoreactive axons from mesencephalic DA cells extended bilaterally in the lateral hypothalamus at embryonic day 12.5 (E12.5) and project to the ipsilateral striatum by E14.5. In the mutant… CONTINUE READING

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