Aberrant splicing of cyclin-dependent kinase-associated protein phosphatase KAP increases proliferation and migration in glioblastoma.

@article{Yu2007AberrantSO,
  title={Aberrant splicing of cyclin-dependent kinase-associated protein phosphatase KAP increases proliferation and migration in glioblastoma.},
  author={Y M Yu and Xiuli Jiang and Brad S Schoch and Rona S. Carroll and Peter M. Black and Mark D. Johnson},
  journal={Cancer research},
  year={2007},
  volume={67 1},
  pages={130-8}
}
The cyclin-dependent kinase (Cdk)-associated protein phosphatase KAP is a dual-specificity phosphatase of which the only known function is to dephosphorylate Cdk2 and inhibit cell cycle progression. Paradoxically, we find increased KAP mRNA expression in malignant astrocytomas, which correlates with increasing histologic grade and decreased patient survival. We have resolved this apparent paradox with the discovery of aberrant KAP splicing in malignant astrocytomas that leads to increased… CONTINUE READING
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