Aberrant signaling of TGF-beta1 by the mutant Smad4 in gastric cancer cells.

@article{Ju2003AberrantSO,
  title={Aberrant signaling of TGF-beta1 by the mutant Smad4 in gastric cancer cells.},
  author={Hyang Ran Ju and Uhee Jung and Chung Hee Sonn and Suk Ran Yoon and Jun Ho Jeon and Young Yang and Kee Nyung Lee and Inpyo Choi},
  journal={Cancer letters},
  year={2003},
  volume={196 2},
  pages={197-206}
}
TGF-beta1 has been known to suppress the growth of gastric cancer cells. Interestingly, TGF-beta1 treatment increased the proliferation of human gastric cancer cell line, SNU-216 cells, while it reduced the proliferation of other tumor cells including SNU-620 cells. TGF-beta1-mediated down-regulation of c-Myc and induction of p21CIP1 were observed in SNU-620, but there was no change in SNU-216 in response to TGF-beta1. Similarly, TGF-beta1 receptors were upregulated by TGF-beta1 treatment in… CONTINUE READING