Aberrant serum hyaluronan and hyaluronidase levels in scleroderma.

  title={Aberrant serum hyaluronan and hyaluronidase levels in scleroderma.},
  author={Birgit A Neudecker and Robert Stern and M. Kari Connolly},
  journal={The British journal of dermatology},
  volume={150 3},
BACKGROUND Scleroderma, or systemic sclerosis, is characterized by aberrations of extracellular matrix deposition. These changes parallel early stages of wound healing when increased deposition of hyaluronan (HA) and collagen occur. Both processes result ultimately in the formation of fibrotic scar tissue. Activities of HA synthase and hyaluronidase, the enzymes that synthesize and degrade HA, are critical in HA turnover. Both become elevated whenever increased matrix deposition occurs. HA… CONTINUE READING
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