Aberrant reward processing in Parkinson's disease is associated with dopamine cell loss

@article{Aarts2012AberrantRP,
  title={Aberrant reward processing in Parkinson's disease is associated with dopamine cell loss},
  author={Esther Aarts and Rick C. Helmich and Marcel J. R. Janssen and Wim J. G. Oyen and Bastiaan R. Bloem and Roshan Cools},
  journal={NeuroImage},
  year={2012},
  volume={59},
  pages={3339-3346}
}
Dopamine has been implicated in reward-related impulsivity, but the exact relationship between dopamine, reward and impulsivity in humans remains unknown. We address this question in Parkinson's disease (PD), which is characterized by severe dopamine depletion. PD is associated primarily with motor and cognitive inflexibility, but can also be accompanied by reward-related impulsivity. This paradoxical symptom of PD has often been attributed to dopaminergic overstimulation by antiparkinson… CONTINUE READING

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