Aberrant reproductive phenotypes evident in transgenic mice expressing the wild-type mouse estrogen receptor.

@article{Davis1994AberrantRP,
  title={Aberrant reproductive phenotypes evident in transgenic mice expressing the wild-type mouse estrogen receptor.},
  author={Vicki L. Davis and John F. Couse and Eugenia H. Goulding and Susan Power and E Mitchell Eddy and Kenneth S. Korach},
  journal={Endocrinology},
  year={1994},
  volume={135 1},
  pages={379-86}
}
The estrogen receptor (ER) acts as a transcription factor to regulate multiple cellular functions involved in normal physiology, differentiation, and reproduction. To date, there is no known animal model for studying aberrant ER expression. Therefore, we created transgenic mice expressing the wild-type mouse ER under the control of the mouse metallothionein-I (MT) promoter to determine whether overexpression of the ER would disrupt normal reproductive processes. Five male and one female founder… CONTINUE READING

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