Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform.

Abstract

Alternative splice variants of fibroblast growth factor receptor 2 (FGFR2) IIIb, designated C1, C2, and C3, possess progressive reduction in their cytoplasmic carboxyl termini (822, 788, and 769 residues, respectively), with preferential expression of the C2 and C3 isoforms in human cancers. We determined that the progressive deletion of carboxyl-terminal… (More)
DOI: 10.1074/jbc.M803998200

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@article{Cha2009AberrantRI, title={Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform.}, author={Jiyoung Y. Cha and Savitri Maddileti and Natalia Mitin and T. Kendall Harden and Channing J Der}, journal={The Journal of biological chemistry}, year={2009}, volume={284 10}, pages={6227-40} }