Aberrant promoter methylation of the RASSF1A and APC genes in epithelial ovarian carcinoma development

@article{Bhagat2012AberrantPM,
  title={Aberrant promoter methylation of the RASSF1A and APC genes in epithelial ovarian carcinoma development},
  author={Rahul Bhagat and Shilpa Chadaga and C. S. Premalata and Gawari Ramesh and Chinnasamy Ramesh and V. R. Pallavi and Lakshmi Krishnamoorthy},
  journal={Cellular Oncology},
  year={2012},
  volume={35},
  pages={473-479}
}
Tumor suppressor gene (TSG) silencing through promoter hypermethylation plays an important role in cancer development. The aim of this study was to assess the extent of methylation of the RASSF1A and APC TSG promoters in ovarian epithelial adenomas, low malignant potential tumours and carcinomas in order to reveal a role for epigenetic TSG silencing in the development of these ovarian malignancies. The promoter methylation status of the RASSF1A and APC genes was assessed in 19 benign… CONTINUE READING
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