Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers.

@article{Takahashi2006AberrantPM,
  title={Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers.},
  author={Takao Takahashi and Hisayuki Shigematsu and Narayan Shivapurkar and Jyotsna L Reddy and Yingye Zheng and Ziding Feng and Makoto Suzuki and Masaharu Nomura and Meena Augustus and J. -H. Yin and Stephen J. Meltzer and Adi F. Gazdar},
  journal={International journal of cancer},
  year={2006},
  volume={118 4},
  pages={924-31}
}
Aberrant methylation of 5'gene promoter regions associated with gene silencing is an epigenetic phenomenon responsible for silencing of tumor suppressor genes in many cancer types. The aims of our study were to study the role of methylation of a large panel of genes during multistage pathogenesis and to correlate our findings with patient age and other clinico-pathological features. We investigated the aberrant promoter methylation profile of 19 genes in 92 colorectal cancers (CRCs) and… CONTINUE READING

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