Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers.

  title={Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers.},
  author={Takao Takahashi and Hisayuki Shigematsu and Narayan Shivapurkar and Jyotsna L Reddy and Yingye Zheng and Ziding Feng and Makoto Suzuki and Masaharu Nomura and Meena Augustus and J. -H. Yin and Stephen J. Meltzer and Adi F. Gazdar},
  journal={International journal of cancer},
  volume={118 4},
Aberrant methylation of 5'gene promoter regions associated with gene silencing is an epigenetic phenomenon responsible for silencing of tumor suppressor genes in many cancer types. The aims of our study were to study the role of methylation of a large panel of genes during multistage pathogenesis and to correlate our findings with patient age and other clinico-pathological features. We investigated the aberrant promoter methylation profile of 19 genes in 92 colorectal cancers (CRCs) and… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 20 extracted citations

RUNX3 Has an Oncogenic Role in Head and Neck Cancer

PloS one • 2009
View 4 Excerpts
Highly Influenced

Epigenetics and maternal nutrition: nature v. nurture.

The Proceedings of the Nutrition Society • 2011


Publications referenced by this paper.
Showing 1-10 of 65 references

The epigenetics of colorectal cancer.

Annals of the New York Academy of Sciences • 2000
View 16 Excerpts
Highly Influenced

CpG island methylator phenotypes in aging and cancer.

Seminars in cancer biology • 1999
View 15 Excerpts
Highly Influenced

Aberrant methylation of SOCS-1 was observed in younger colorectal cancer patients

Journal of Gastroenterology • 2003
View 8 Excerpts
Highly Influenced

DNA methylation profiles of lymphoid and hematopoietic malignancies.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2004
View 1 Excerpt

Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2003

Cancer statistics, 2003.

CA: a cancer journal for clinicians • 2003

Similar Papers

Loading similar papers…