Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers.

@article{Yano2005AberrantPM,
  title={Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers.},
  author={Masaaki Yano and Shinichi Toyooka and Kazunori Tsukuda and Hideaki Dote and Mamoru Ouchida and Tetsuro Hanabata and Motoi Aoe and Hiroshi Date and Adi F. Gazdar and Nobuyoshi Shimizu},
  journal={International journal of cancer},
  year={2005},
  volume={113 1},
  pages={59-66}
}
The human DOC-2/DAB2 interactive protein gene (hDAB2IP) is a novel member of the Ras GTPase-activating gene family that is known to act as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers. We established previously a methylation-specific PCR (MSP) for the promoter region (m2a and m2b regions) of hDAB2IP and examined hDAB2IP methylation status in breast cancers. We analyzed the methylation and expression status of hDAB2IP in lung cancers. The methylation… CONTINUE READING
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