Aberrant promoter hypermethylation of multiple genes in head and neck squamous cell carcinoma.

@article{Puri2005AberrantPH,
  title={Aberrant promoter hypermethylation of multiple genes in head and neck squamous cell carcinoma.},
  author={Sajeev K Puri and Lingbao Si and Chun-Yang Fan and E Lex Hanna},
  journal={American journal of otolaryngology},
  year={2005},
  volume={26 1},
  pages={12-7}
}
PURPOSE Epigenetic alteration, via promoter hypermethylation, inactivates genes important for the development of head and neck squamous cell carcinoma (SCCHN). The aim of this study is to characterize and correlate, with clinical parameters, the promoter methylation profile of DNA repair genes, hMLH1 and O6-methylguanine-DNA methyltransferase (MGMT), and tumor-suppressor gene p16. MATERIALS AND METHODS Fifty-one cases of SCCHN, collected from the paraffin block archives (1997-1999) in the… CONTINUE READING

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