Aberrant promoter hypermethylation and genomic hypomethylation in tumor, adjacent normal tissues and blood from breast cancer patients.

@article{Cho2010AberrantPH,
  title={Aberrant promoter hypermethylation and genomic hypomethylation in tumor, adjacent normal tissues and blood from breast cancer patients.},
  author={Yoon H Cho and Hulya Yazici and Hui-Chen Wu and Mary Beth Terry and Karina Gonz{\'a}lez and Mengxue Qu and Nejat Dalay and Regina M. Santella},
  journal={Anticancer research},
  year={2010},
  volume={30 7},
  pages={2489-96}
}
BACKGROUND Promoter hypermethylation and global hypomethylation in the human genome are hallmarks of most cancers. Detection of aberrant methylation in white blood cells (WBC) has been suggested as a marker for cancer development, but has not been extensively investigated. This study was carried out to determine whether aberrant methylation in WBC DNA can be used as a surrogate biomarker for breast cancer risk. PATIENTS AND METHODS Promoter hypermethylation of 8 tumor suppressor genes… CONTINUE READING

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