Aberrant platelet-derived growth factor alpha-receptor transcript as a diagnostic marker for early human germ cell tumors of the adult testis.

@article{Mosselman1996AberrantPG,
  title={Aberrant platelet-derived growth factor alpha-receptor transcript as a diagnostic marker for early human germ cell tumors of the adult testis.},
  author={Sietse Mosselman and Leendert H. J. Looijenga and Ad J. M. Gillis and Marga A van Rooijen and Harry Kraft and Everardus J. van Zoelen and J Wolter Oosterhuis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 7},
  pages={2884-8}
}
Testicular germ cell tumors are the most common form of cancer in young adult males. They result from a derangement of primordial germ cells, and they grow out from a noninvasive carcinoma-in-situ precursor. Since carcinoma in situ can readily be cured by low-dose irradiation, there is a great incentive for non- or minimally invasive methods for detection of carcinoma in situ. We have recently shown that human Tera-2 embryonal carcinoma cells, obtained from a nonseminomatous testicular germ… CONTINUE READING

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