Aberrant patterns of X chromosome inactivation in bovine clones

  title={Aberrant patterns of X chromosome inactivation in bovine clones},
  author={Fei Xue and X. Tian and F. Du and C. Kubota and M. Taneja and A. Dinny{\'e}s and Y. Dai and H. Levine and Lygia V. Pereira and X. Yang},
  journal={Nature Genetics},
  • Fei Xue, X. Tian, +7 authors X. Yang
  • Published 2002
  • Biology, Medicine
  • Nature Genetics
  • In mammals, epigenetic marks on the X chromosomes are involved in dosage compensation. Specifically, they are required for X chromosome inactivation (XCI), the random transcriptional silencing of one of the two X chromosomes in female cells during late blastocyst development. During natural reproduction, both X chromosomes are active in the female zygote. In somatic-cell cloning, however, the cloned embryos receive one active (Xa) and one inactive (Xi) X chromosome from the donor cells… CONTINUE READING
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