Aberrant patterns of X chromosome inactivation in bovine clones

@article{Xue2002AberrantPO,
  title={Aberrant patterns of X chromosome inactivation in bovine clones},
  author={Fei Xue and X Cindy Tian and Fuliang Du and Chikara Kubota and Maneesh Taneja and Andras Dinnyes and Yunping Dai and Howard Levine and Lygia V. Pereira and Xiangzhong Yang},
  journal={Nature Genetics},
  year={2002},
  volume={31},
  pages={216-220}
}
  • Fei Xue, X Cindy Tian, +7 authors Xiangzhong Yang
  • Published in Nature Genetics 2002
  • DOI:10.1038/ng900
In mammals, epigenetic marks on the X chromosomes are involved in dosage compensation. Specifically, they are required for X chromosome inactivation (XCI), the random transcriptional silencing of one of the two X chromosomes in female cells during late blastocyst development1,2,3,4,5,6,7,8. During natural reproduction, both X chromosomes are active in the female zygote2. In somatic-cell cloning, however, the cloned embryos receive one active (Xa) and one inactive (Xi) X chromosome from the… CONTINUE READING
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