Aberrant p21WAF1-dependent growth arrest as the possible mechanism of abnormal resistance to ultraviolet light cytotoxicity in Li–Fraumeni syndrome fibroblast strains heterozygous for TP53 mutations

@article{Barley1998AberrantPG,
  title={Aberrant p21WAF1-dependent growth arrest as the possible mechanism of abnormal resistance to ultraviolet light cytotoxicity in Li–Fraumeni syndrome fibroblast strains heterozygous for TP53 mutations},
  author={Randy DC Barley and Louise Enns and Malcolm C. Paterson and Razmik Mirzayans},
  journal={Oncogene},
  year={1998},
  volume={17},
  pages={533-543}
}
The purpose of this study is to better understand the roles of the p53 tumor suppressor protein and the product of the p53-regulated gene p21WAF1 in the response of diploid human dermal fibroblast cultures to 254 nm ultraviolet (UV) light. We report that Li–Fraumeni syndrome (LFS) fibroblast strains heterozygous for TP53 mutation at either codon 245 or 234 exhibit markedly reduced or no expression of p21WAF1 following UV irradiation, respectively. These strains also exhibit defective nucleotide… CONTINUE READING

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