Aberrant overexpression of EZH2 and H3K27me3 serves as poor prognostic biomarker for esophageal squamous cell carcinoma patients.

@article{Liu2016AberrantOO,
  title={Aberrant overexpression of EZH2 and H3K27me3 serves as poor prognostic biomarker for esophageal squamous cell carcinoma patients.},
  author={Fei Liu and Lina Gu and Yu Cao and Xiaojie Fan and Fengjuan Zhang and Meixiang Sang},
  journal={Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals},
  year={2016},
  volume={21 1},
  pages={80-90}
}
It has been reported that the trimethylation of histone 3 on lysine 27 (H3K27me3) is required for enhancer of zeste homology 2 (EZH2)-mediated repression of various genes essential for tumorigenesis and tumor development. Here, we reported the expression of EZH2 and H3K27me3 in esophageal squamous cell carcinoma (ESCC) specimens was higher than the pericarcinoma esophageal specimens. Their expression was positively associated with the poor prognosis of ESCC patients. EZH2 expression… CONTINUE READING