Aberrant neuregulin 1 signaling in amyotrophic lateral sclerosis.

  title={Aberrant neuregulin 1 signaling in amyotrophic lateral sclerosis.},
  author={Fei Song and Pohung Chiang and JiaJing Wang and John Ravits and Jeffrey A. Loeb},
  journal={Journal of neuropathology and experimental neurology},
  volume={71 2},
Neuregulin 1 (NRG1) is a neuron-derived trophic molecule that supports axoglial and neuromuscular development through several alternatively spliced isoforms; its possible role in the pathogenesis and progression of amyotrophic lateral sclerosis (ALS) is not known. We analyzed the relationship of NRG1 isoform expression to glial cell activation and motor neuron loss in spinal cords of ALS patients and during disease progression in the superoxide dismutase 1 (SOD1) ALS mouse model. Microgliosis… CONTINUE READING