Aberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumors.

@article{Toyota2000AberrantMO,
  title={Aberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumors.},
  author={Minoru Toyota and Liangliang Shen and Mutsumi Ohe-Toyota and Stanley R. Hamilton and Frank A. Sinicrope and Jean-Pierre Issa},
  journal={Cancer research},
  year={2000},
  volume={60 15},
  pages={4044-8}
}
Cyclooxygenases (COXs) are key enzymes that convert arachidonic acid to prostaglandins. Overexpression of one of the COX isozymes, COX2, has been shown to play an important role in colorectal cancer progression. Recently, however, low expression of COX2 has been reported in a subset of colorectal and gastric cancers. Aberrant CpG island methylation and… CONTINUE READING