Aberrant methylation of the CDH13 (H-cadherin) promoter region in colorectal cancers and adenomas.

@article{Toyooka2002AberrantMO,
  title={Aberrant methylation of the CDH13 (H-cadherin) promoter region in colorectal cancers and adenomas.},
  author={Shinichi Toyooka and Kiyomi O. Toyooka and Kenichi Harada and Kuniharu Miyajima and Prakash B Makarla and Ubaradka G. Sathyanarayana and Jing Yin and Fumiaki Sato and Narayan Shivapurkar Shivapurkar and Stephen J. Meltzer and Adi F. Gazdar},
  journal={Cancer research},
  year={2002},
  volume={62 12},
  pages={
          3382-6
        }
}
Expression of the cadherin family member CDH13 (H-cadherin) is reduced in several human tumors, and it has been hypothesized that this gene functions as a tumor suppressor gene. Previously, we reported that the 5' region of CDH13 is frequently methylated in breast and lung cancers. Here we confirmed the promoter activity of 5' region of CDH13 by luciferase assay and examined its aberrant methylation in colorectal cancers, cell lines, and adenomas. Methylation status was investigated by… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 29 REFERENCES

Aberrant promoter methylation profile of prostate cancers and its relationship to clinicopathological features.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2002

HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
VIEW 1 EXCERPT

Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

Joseph F. Costello, Michael C. Frühwald, +20 authors Christoph Plass
  • Nature Genetics
  • 2000
VIEW 1 EXCERPT

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