Aberrant methylation of protocadherin 17 and its prognostic value in pediatric acute lymphoblastic leukemia.


BACKGROUND The outcome of approximately 20% of patients with acute lymphoblastic leukemia (ALL) remains poor because of disease recurrence. We examined whether DNA methylation of cadherin superfamily genes is a useful biomarker for ALL relapse. PROCEDURE We used Infinium Methylation 450K Arrays to assess genome-wide DNA methylation status. The methylation… (More)
DOI: 10.1002/pbc.26259


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