Aberrant methylation of integrin α4 gene in human gastric cancer cells

@article{Park2004AberrantMO,
  title={Aberrant methylation of integrin α4 gene in human gastric cancer cells},
  author={Jinah Park and Sang-Hyun Song and Tai Young Kim and Moon-Chang Choi and Hyun-Soon Jong and T. -Y. Kim and Jung Weon Lee and Noe Kyeong Kim and W Kim and Yung-jue Bang},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={3474-3480}
}
Integrins are adhesion receptors that mediate both cell–extracellular matrix and cell–cell interactions. It has also been reported that the loss of integrin α4 expression might be associated with metastasis in several cancers. However, the molecular mechanism for loss of their expression in cancers has not been explored. In the present study, we found that the integrin α4 expression is lost in human gastric cancer cell lines and that this is recovered by treatment with DNA methyltransferase… CONTINUE READING
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