Aberrant methylation of hypermethylated-in-cancer-1 and exocyclic DNA adducts in tobacco smokers.

@article{Peluso2014AberrantMO,
  title={Aberrant methylation of hypermethylated-in-cancer-1 and exocyclic DNA adducts in tobacco smokers.},
  author={Marco Peluso and Armelle Munnia and Valentina Bollati and Petcharin Srivatanakul and Adisorn Jedpiyawongse and Suleeporn Sangrajrang and Marcello Ceppi and Roger W. Giese and Paolo Boffetta and Andrea A. Baccarelli},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2014},
  volume={137 1},
  pages={47-54}
}
Tobacco smoke has been shown to produce both DNA damage and epigenetic alterations. However, the potential role of DNA damage in generating epigenetic changes is largely underinvestigated in human studies. We examined the effects of smoking on the levels of DNA methylation in genes for tumor protein p53, cyclin-dependent kinase inhibitor2A, hypermethylated-in-cancer-1 (HIC1), interleukin-6, Long Interspersed Nuclear Element type1, and Alu retrotransposons in blood of 177 residents in Thailand… CONTINUE READING