Aberrant methylation of gene promoters in cancer---concepts, misconcepts, and promise.

@article{Baylin2000AberrantMO,
  title={Aberrant methylation of gene promoters in cancer---concepts, misconcepts, and promise.},
  author={Stephen B. Baylin and Steven Alan Belinsky and James G. Herman},
  journal={Journal of the National Cancer Institute},
  year={2000},
  volume={92 18},
  pages={1460-1}
}
In this issue of the Journal, Tang et al. (1) report that the presence of abnormal methylation in the 5 region of the deathassociated protein (DAP) gene in tumor DNA predicts shorter survival in patients who had undergone surgery for non-smallcell lung cancer (NSCLC). This change in methylation is an example of an epigenetic process that is attracting increasing attention, both because of its potential significance to our basic understanding of cancer and because of its possible use for… CONTINUE READING

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