Aberrant methylation of donor genome in cloned bovine embryos

@article{Kang2001AberrantMO,
  title={Aberrant methylation of donor genome in cloned bovine embryos},
  author={Yong Kook Kang and Deog-Bon Koo and Jung-Sun Park and Young-hee Choi and A Chung and Kyung-kwang Lee and Yong-Mahn Han},
  journal={Nature Genetics},
  year={2001},
  volume={28},
  pages={173-177}
}
Despite recent successes in cloning various animal species, the use of somatic cells as the source of donor nuclei has raised many practically relevant questions such as increased abortion rates, high birth weight and perinatal death1,2,3. These anomalies may be caused by incomplete epigenetic reprogramming of donor DNA. Genome-wide demethylation occurs during early development, 'erasing' gamete-specific methylation patterns inherited from the parents4,5,6,7,8. This process may be a… CONTINUE READING

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