Aberrant localization of beta-catenin correlates with overexpression of its target gene in human papillary thyroid cancer.

@article{Ishigaki2002AberrantLO,
  title={Aberrant localization of beta-catenin correlates with overexpression of its target gene in human papillary thyroid cancer.},
  author={Katsu Ishigaki and Hiroyuki Namba and Masahiro Nakashima and Toshiyuki Nakayama and Norisato Mitsutake and Tomayoshi Hayashi and Shigeto Maeda and Makoto Ichinose and Takashi Kanematsu and Shunichi Yamashita},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 7},
  pages={3433-40}
}
Alterations of the Wnt/beta-catenin signaling pathway are known to occur in mutations of the component genes such as APC, Axin, and beta-catenin, and play a pathogenetic role in tumorigenesis. Activated Wnt signaling stabilizes beta-catenin, which associates with T cell factor, resulting in transactivation of the downstream target genes including c-myc and cyclin D1. To investigate the involvement of Wnt/beta-catenin signaling pathway in thyroid tumorigenesis, we analyzed its activation and… CONTINUE READING

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