Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy.

@article{Kabuta2008AberrantIB,
  title={Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy.},
  author={Tomohiro Kabuta and Akiko Furuta and Shunsuke Aoki and Koh Furuta and Keiji Wada},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 35},
  pages={
          23731-8
        }
}
Parkinson disease (PD) is the most common neurodegenerative movement disorder. An increase in the amount of alpha-synuclein protein could constitute a cause of PD. Alpha-synuclein is degraded at least partly by chaperone-mediated autophagy (CMA). The I93M mutation in ubiquitin C-terminal hydrolase L1 (UCH-L1) is associated with familial PD. However, the relationship between alpha-synuclein and UCH-L1 in the pathogenesis of PD has remained largely unclear. In this study, we found that UCH-L1… CONTINUE READING
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