Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus

@article{Kobasa2007AberrantII,
  title={Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus},
  author={Darwyn Kobasa and Steven J M Jones and Kyoko Shinya and John C Kash and John S Copps and Hideki Ebihara and Yasuko Hatta and Jin Hyun Kim and Peter J. Halfmann and Masato Hatta and Friederike Feldmann and Judie B. Alimonti and Lisa Fernando and Yan Li and Michael G. Katze and Heinz Feldmann and Yoshihiro Kawaoka},
  journal={Nature},
  year={2007},
  volume={445},
  pages={319-323}
}
The 1918 influenza pandemic was unusually severe, resulting in about 50 million deaths worldwide. The 1918 virus is also highly pathogenic in mice, and studies have identified a multigenic origin of this virulent phenotype in mice. However, these initial characterizations of the 1918 virus did not address the question of its pathogenic potential in primates. Here we demonstrate that the 1918 virus caused a highly pathogenic respiratory infection in a cynomolgus macaque model that culminated in… Expand
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