Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus

  title={Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus},
  author={D. Kobasa and S. Jones and K. Shinya and J. C. Kash and J. Copps and Hideki Ebihara and Yasuko Hatta and J. Kim and P. Halfmann and M. Hatta and F. Feldmann and J. Alimonti and L. Fernando and Y. Li and M. Katze and H. Feldmann and Y. Kawaoka},
  • D. Kobasa, S. Jones, +14 authors Y. Kawaoka
  • Published 2007
  • Medicine, Biology
  • Nature
  • The 1918 influenza pandemic was unusually severe, resulting in about 50 million deaths worldwide. The 1918 virus is also highly pathogenic in mice, and studies have identified a multigenic origin of this virulent phenotype in mice. However, these initial characterizations of the 1918 virus did not address the question of its pathogenic potential in primates. Here we demonstrate that the 1918 virus caused a highly pathogenic respiratory infection in a cynomolgus macaque model that culminated in… CONTINUE READING
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