Aberrant in Vivo T Helper Type 2 Cell Response and Impaired Eosinophil Recruitment in Cc Chemokine Receptor 8 Knockout Mice

@article{Chensue2001AberrantIV,
  title={Aberrant in Vivo T Helper Type 2 Cell Response and Impaired Eosinophil Recruitment in Cc Chemokine Receptor 8 Knockout Mice},
  author={Stephen W. Chensue and Nicholas W Lukacs and T T Yang and Xiaozhou Shang and Kirsten A. Frait and Steven L. Kunkel and Ted T Kung and Maria T. Wiekowski and Joseph A. Hedrick and Donald N. Cook and Alessandra Zingoni and Satwant K. Narula and Albert Zlotnik and Franck J Barrat and Anne O'Garra and Monica Napolitano and Sergio A Lira},
  journal={The Journal of Experimental Medicine},
  year={2001},
  volume={193},
  pages={573 - 584}
}
Chemokine receptors transduce signals important for the function and trafficking of leukocytes. Recently, it has been shown that CC chemokine receptor (CCR)8 is selectively expressed by Th2 subsets, but its functional relevance is unclear. To address the biological role of CCR8, we generated CCR8 deficient (-/-) mice. Here we report defective T helper type 2 (Th2) immune responses in vivo in CCR8(-/)- mice in models of Schistosoma mansoni soluble egg antigen (SEA)-induced granuloma formation as… CONTINUE READING

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