Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1

@article{Metcalf1999AberrantHI,
  title={Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1},
  author={Donald Metcalf and W F Alexander and A Elefanty and N A Nicola and D Hilton and Robyn Starr and Sandra Mifsud and L Di Rago},
  journal={Leukemia},
  year={1999},
  volume={13},
  pages={926-934}
}
Mice with homozygous inactivation of the gene encoding the suppressor of cytokine signaling-1 (SOCS-1) protein die within 21 days of birth with low body weight, fatty degeneration and necrosis of the liver, infiltration of the lung, pancreas, heart and skin by macrophages and granulocytes and a profound depletion of T- and B-lymphocytes. In the present… CONTINUE READING