Aberrant glutamate signaling in the prefrontal cortex and striatum of the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder

@article{Miller2014AberrantGS,
  title={Aberrant glutamate signaling in the prefrontal cortex and striatum of the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder},
  author={Erin Michelle Miller and François Pomerleau and Peter Huettl and Greg A. Gerhardt and Paul E. A. Glaser},
  journal={Psychopharmacology},
  year={2014},
  volume={231},
  pages={3019-3029}
}
RationaleAttention-deficit/hyperactivity disorder (ADHD) is thought to involve hypofunctional catecholamine systems in the striatum, nucleus accumbens, and prefrontal cortex (PFC); however, recent clinical evidence has implicated glutamate dysfunction in the pathophysiology of ADHD. Recent studies show that increased stimulation of dopamine D2 and D4 receptors causes inhibition of N-methyl-d-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, respectively. The… CONTINUE READING

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