Aberrant gene expression in cultured mammalian bone cells demonstrates an osteoblast defect in osteopetrosis.

@article{Jackson1994AberrantGE,
  title={Aberrant gene expression in cultured mammalian bone cells demonstrates an osteoblast defect in osteopetrosis.},
  author={Maria E Jackson and Victoria Shalhoub and Jane B Lian and Gary S Stein and Sandy C. Marks},
  journal={Journal of cellular biochemistry},
  year={1994},
  volume={55 3},
  pages={366-72}
}
Osteopetrosis is a skeletal condition in which a generalized radioopacity of bone is caused by reduced resorption of bone by osteoclasts. However, it has recently been shown that during skeletal development in several osteopetrotic rat mutations specific aberrations occur in gene expression reflecting the activity of the bone forming cells, osteoblasts, and the development of tissue organization. To evaluate their pathogenetic significance, progressive osteoblast differentiation was studied in… CONTINUE READING