Aberrant frequency of IL-10-producing B cells and its association with Treg and MDSC cells in Non Small Cell Lung Carcinoma patients.

@article{Liu2016AberrantFO,
  title={Aberrant frequency of IL-10-producing B cells and its association with Treg and MDSC cells in Non Small Cell Lung Carcinoma patients.},
  author={Jinlin Liu and Huan Wang and Qinhua Yu and Sujie Zheng and Yangcheng Jiang and Yiyan Liu and Guorong Yuan and Liannv Qiu},
  journal={Human immunology},
  year={2016},
  volume={77 1},
  pages={84-9}
}
OBJECTIVES B regulatory cells (Bregs) are a newly described subpopulation of B cells that play important roles in autoimmunity, however, whether play an important role in cancer is relatively unknown. Herein, we investigated the role of IL-10 producing B cells in Non Small Cell Lung Carcinoma (NSCLC). METHODS 18 healthy controls (HC) and 66 untreated patients with NSCLC were enrolled. Next to IL-10 producing B cells, CD4(+)CD25(+/high)CD127(low/-) regulatory T (Treg) cells and CD14(+)HLA-DR… CONTINUE READING
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