Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression.

@article{Li2007AberrantEO,
  title={Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression.},
  author={Min Li and Yuqing Zhang and Zijuan Liu and Uddalak Bharadwaj and Hao Wang and Xinwen Wang and Sheng Zhang and Juan P Liuzzi and Shou-Mei Chang and Robert J. Cousins and William E. Fisher and Francis Charles Brunicardi and Craig D. Logsdon and Changyi Johnny Chen and Q. -S. Yao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 47},
  pages={18636-41}
}
Zinc is an essential trace element and catalytic/structural component used by many metalloenzymes and transcription factors. Recent studies indicate a possible correlation of zinc levels with the cancer risk; however, the exact role of zinc and zinc transporters in cancer progression is unknown. We have observed that a zinc transporter, ZIP4 (SLC39A4), was substantially overexpressed in 16 of 17 (94%) clinical pancreatic adenocarcinoma specimens compared with the surrounding normal tissues, and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 79 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Pflügers Arch 447:796–800

  • DJ Eide
  • 2004

Aliment Pharmacol Ther 18:837–846

  • M Juhasz, J Chen, +6 authors MP Ebert
  • 2003

Similar Papers

Loading similar papers…