Aberrant expression of tumor suppressor proteins in the Ewing family of tumors.

@article{Maitra2001AberrantEO,
  title={Aberrant expression of tumor suppressor proteins in the Ewing family of tumors.},
  author={Anirban Maitra and Helen A. Roberts and A. G. Weinberg and Joseph Geradts},
  journal={Archives of pathology & laboratory medicine},
  year={2001},
  volume={125 9},
  pages={
          1207-12
        }
}
BACKGROUND Deregulation of tumor suppressor gene function and abrogation of cell cycle control are common features of malignant neoplasms, but corresponding data on Ewing sarcomas and primitive neuroectodermal tumors are relatively scarce. We studied the expression of 4 tumor suppressor proteins in the Ewing family of tumors (EFTs). DESIGN We examined a series of 20 pediatric EFTs for abnormal expression of p16(INK4a), p14(ARF), p21(WAF1), and pRB by immunohistochemical analysis of… CONTINUE READING

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