Aberrant expression of the negative costimulator PD-1 on T cells in granulomatosis with polyangiitis.

@article{Wilde2012AberrantEO,
  title={Aberrant expression of the negative costimulator PD-1 on T cells in granulomatosis with polyangiitis.},
  author={Benjamin G. Wilde and Fan Yan Hua and Sebastian Conrad Johannes Dolff and Cao Jun and Xin Cai and Christof Specker and Thorsten Feldkamp and Andreas Kribben and Jan Willem Cohen Tervaert and Oliver Witzke},
  journal={Rheumatology},
  year={2012},
  volume={51 7},
  pages={
          1188-97
        }
}
OBJECTIVE Persistent T-cell activation is frequently observed in granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis). T-cell activation is usually balanced by negative costimulatory molecules. The negative costimulator programmed death receptor-1 (PD-1) and its relevance to T-cell immunity have not been studied so far in GPA. Thus it is the aim of the study to characterize the role of PD-1 in GPA. METHODS Thirty-two patients suffering from GPA and 19 age-matched… CONTINUE READING

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