Aberrant expression of the myeloid zinc finger gene, MZF-1, is oncogenic.

  title={Aberrant expression of the myeloid zinc finger gene, MZF-1, is oncogenic.},
  author={Robert Hromas and Julie Morris and Kenneth G Cornetta and Dan Berebitsky and Anne Davidson and Muneyasu Sha and George Sledge and Frances Rauscher},
  journal={Cancer research},
  volume={55 16},
The zinc finger gene MZF-1 is preferentially expressed in primitive hematopoietic cells and plays an important role in regulating myelopoiesis. Regulators of development are potential targets for neoplastic transformation. This study investigated whether unregulated expression of MZF-1 could function as an oncogene. Retroviral transduction and subsequent overexpression of MZF-1 resulted in loss of contact inhibition, loss of substrate dependence, and more rapid cell cycling in NIH 3T3 cells… CONTINUE READING

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Characterization of the DNA binding properties of the myeloid zinc finger gene MZF-1: two independent DNAbinding domains recognize two DNA consensus sequences with a common G-rich

  • J. Morris, R. Hromas, F. Rauscher, III
  • core. Mol. Cell. Biol.,
  • 1994
2 Excerpts

Alterations of a zinc finger-encoding gene, belÃ2,in diffuse large cell lymphoma

  • H Ye.B., F. Lista, D LoCoco.F..Knowles., K. Offit, R.S.K. Chaganti, R. Dalla-Favera
  • Science (Washington DC),
  • 1993
1 Excerpt

Fusion between a novel Krupple-like zinc finger gene and the retinoic acid receptor a locus due to a variant t(l Iscmil7) translocation associated with acute promyelocytic leukemia

  • C. Zhen, N. J. Brand, +8 authors A. Zclcnt
  • EMBO J.,
  • 1993
3 Excerpts

Hematopoietic stage and lineage restriction of the ETS oncogene family member PU.l

  • R. Hromas, A. Orazi, +4 authors M. Klemsz
  • Blood
  • 1993

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