Aberrant expression of the maspin gene associated with epigenetic modification in melanoma cells.

@article{Wada2004AberrantEO,
  title={Aberrant expression of the maspin gene associated with epigenetic modification in melanoma cells.},
  author={Kei Wada and Chihaya Maesawa and Toshihide Akasaka and Tomoyuki Masuda},
  journal={The Journal of investigative dermatology},
  year={2004},
  volume={122 3},
  pages={
          805-11
        }
}
Maspin, a mammary serine protease inhibitor, was originally reported to be a tumor suppressor gene in breast and prostate cancers. The expression pattern of the maspin gene differs among cancer types and normal tissue however, and its significance as a tumor suppressor has been questioned. In this study, maspin expression and/or allele-specific methylation status were investigated in five melanoma cell lines and a normal human epidermal melanocyte (NHEM) cell line, and 80 surgically resected… CONTINUE READING

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Role of maspin in cancer

  • Clinical and Translational Medicine
  • 2013
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