Aberrant expression of the gene for lens major intrinsic protein in the CAT mouse.

Abstract

Immunocytochemistry fails to detect expression of the lens major intrinsic protein (MIP) in 16-day embryos of the congenitally cataractous mouse, CAT, which inherits a dominant mutation assigned to the distal end of mouse chromosome 10. In situ hybridisation, however, detects MIP mRNA in CAT embryo lens fibre cells at a level approximating 60% of that… (More)

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