Aberrant expression of the constitutive endothelial nitric oxide synthase gene in Alzheimer disease.

@article{Monte1997AberrantEO,
  title={Aberrant expression of the constitutive endothelial nitric oxide synthase gene in Alzheimer disease.},
  author={Suzanne de la Monte and Kenneth D. Bloch},
  journal={Molecular and chemical neuropathology},
  year={1997},
  volume={30 1-2},
  pages={139-59}
}
Neuritic pathology is a major neuroanatomical correlate of dementia in Alzheimer disease (AD). Nitric oxide (NO) is linked to neuritic growth and synaptic plasticity. Expression of one of the enzymes responsible for NO synthesis, the constitutive endothelial NO synthase (ceNOS), was investigated in brains of AD and Down syndrome patients using RNase protection assays, in situ hybridization, and immunocytochemistry. In end-stage AD, ceNOS expression was reduced in cortical neurons, and the… CONTINUE READING
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