Aberrant expression of the Rb pathway proteins in soft tissue sarcomas.

  title={Aberrant expression of the Rb pathway proteins in soft tissue sarcomas.},
  author={Muna Sabah and Robert J. Cummins and M. Sc. Sally WilsonProject Leader and Elaine B Kay},
  journal={Applied immunohistochemistry & molecular morphology : AIMM},
  volume={14 4},
Cell cycle regulation depends on a fine balance between cyclins, cyclin-dependent kinases (CDKs), and cyclin-dependent kinase inhibitors (CKIs) that block the cycle progression. Alterations of the cell cycle regulators are a common feature of many malignant tumors, and some have been shown to have prognostic significance. In this study, 152 cases of different types of soft tissue sarcomas were evaluated for alterations of cell cycle regulator proteins that control the cell cycle progression… CONTINUE READING


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