Aberrant expression of p53 and retinoblastoma gene products in human esophageal squamous cell carcinoma.


The aberrant expression of p53 and RB proteins was investigated by immunohistochemistry in 73 patients with esophageal SCC, who underwent esophageal resection. Fresh tumor tissues from 21 patients were also tested for p53 mutations in exons 4 through 9 by direct sequencing. Positive nuclear staining with p53 antibody in cancer cells was found in 49.3% (36… (More)