Aberrant expression of glycogen synthase kinase-3β in human breast and head and neck cancer

@inproceedings{Ugolkov2018AberrantEO,
  title={Aberrant expression of glycogen synthase kinase-3β in human breast and head and neck cancer},
  author={Andrey V. Ugolkov and Maria Matsangou and Timothy J. Taxter and Thomas V O'Halloran and Vincent L Cryns and Francis J Giles and Andrew P. Mazar},
  booktitle={Oncology letters},
  year={2018}
}
Glycogen Synthase Kinase-3β (GSK-3β), a serine/threonine protein kinase, has been implicated as a potential therapeutic target in human cancer. The objective of the present study was to evaluate aberrant expression of GSK-3β as a potential biomarker in human breast and head and neck cancers. Nuclear/cytosolic fractionation, immunoblotting and immunohistochemical staining was used to study the expression of GSK-3β in human breast and head and neck cancer. Aberrant nuclear accumulation of GSK-3… CONTINUE READING

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