Aberrant expression of gap junction gene in primary human hepatocellular carcinomas: increased expression of cardiac-type gap junction gene connexin 43.

@article{Oyamada1990AberrantEO,
  title={Aberrant expression of gap junction gene in primary human hepatocellular carcinomas: increased expression of cardiac-type gap junction gene connexin 43.},
  author={Masahito Oyamada and Vladimir A Krutovskikh and Marc Mesnil and Christian C-M Partensky and François Berger and Hiroshi Yamasaki},
  journal={Molecular carcinogenesis},
  year={1990},
  volume={3 5},
  pages={273-8}
}
The expression of connexin 32 (the major liver gap junction protein) and connexin 43 (the major cardiac gap junction protein) was examined in six surgically removed human hepatocellular carcinoma tissues and the surrounding nontumorous livers using specific rat connexin probes. No decrease in connexin 32 mRNA expression was found in carcinomas compared with the surrounding nontumorous tissue. Morphometrical analysis also showed that in most of the carcinomas the number of gap junction spots… CONTINUE READING