Aberrant expression of cortactin and fascin are effective markers for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas.

@article{Li2008AberrantEO,
  title={Aberrant expression of cortactin and fascin are effective markers for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas.},
  author={Xiaohan Li and Hua-Chuan Zheng and Takuo Hara and Hiroyuki Takahashi and Shinji Masuda and Zhigang Wang and Xianghong Yang and Yi-fu Guan and Yasuo Takano},
  journal={International journal of oncology},
  year={2008},
  volume={33 1},
  pages={69-79}
}
Tumor metastasis depends on cell adhesiveness, motility and deformability, resulting from quantitative alterations and rearrangement of various actin-binding cytoskeletal components, such as cortactin and fascin. To clarify the involvement of cortactin and fascin expression in tumorigenesis and progression of gastric carcinoma, we performed immunohistochemistry (IHC) on tissue microarray containing gastric carcinomas, adenomas and adjacent non-neoplastic mucosa (ANNM) using the antibodies… CONTINUE READING

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