Aberrant expression of chemokine receptor CCR4 in human gastric cancer contributes to tumor-induced immunosuppression.

@article{Yang2011AberrantEO,
  title={Aberrant expression of chemokine receptor CCR4 in human gastric cancer contributes to tumor-induced immunosuppression.},
  author={Yong-mei Yang and A-lei Feng and Cheng-jun Zhou and Xiao-hong Liang and Hai-ting Mao and Bi-ping Deng and Shi Yan and Jin-Tang Sun and Lu-tao Du and Jian Liu and Qing-jie Wang and Markus R Neckenig and Qi-feng Yang and Xun Qu},
  journal={Cancer science},
  year={2011},
  volume={102 7},
  pages={1264-71}
}
The chemokine receptor CCR4 is preferentially expressed on certain immune cells and some hematological tumor cells, which play pivotal roles in suppression of host immune response. However, the reasons for the upmodulation of CCR4 and its immune functions in solid tumors remain unclear. Herein, we aimed to determine the expression profiles of CCR4 in gastric cancer cells and its role in regulating antitumor immunity. CCR4 expression was assessed in 63 cases of gastric carcinomas by… CONTINUE READING