Aberrant expression of active leukotriene C(4) synthase in CD16(+) neutrophils from patients with chronic myeloid leukemia.

@article{Sjlinder2000AberrantEO,
  title={Aberrant expression of active leukotriene C(4) synthase in CD16(+) neutrophils from patients with chronic myeloid leukemia.},
  author={Mikael Sj{\"o}linder and Leif Stenke and Barbro N{\"a}sman-Glaser and Susanne Widell and J Doucet and P J Jakobsson and Jan Ake Lindgren},
  journal={Blood},
  year={2000},
  volume={95 4},
  pages={1456-64}
}
Elevated leukotriene (LT)C(4) synthase activity was observed in peripheral blood granulocyte suspensions from patients with chronic myeloid leukemia (CML). Magnetic cell sorting (MACS) with CD16 monoclonal antibodies (mAbs), which were used to fractionate granulocytes from CML patients and healthy individuals, yielded highly purified suspensions of CD16(+) neutrophils. The purity of these cell fractions was verified by extensive morphologic examination. Reverse transcriptase-polymerase chain… CONTINUE READING

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Characterization of a leukotriene C 4 export mechanism in human plateletsPossible involvement of multidrug resistenceassociated protein 1

M Sjölinder, S Tornhamre, Claesson H-E, JÅ Lindgren
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