Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions.

@article{Park2008AberrantEO,
  title={Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions.},
  author={Eun Taek Park and James R. Gum and Sanjay Kakar and Sung Won Kwon and Guoren Deng and Young Ju Kim},
  journal={International journal of cancer},
  year={2008},
  volume={122 6},
  pages={1253-60}
}
Mucinous colorectal cancers are characterized by abundant production of intestinal goblet cell mucin, MUC2 and frequent ectopic expression of gastric foveolar mucin, MUC5AC. SOX2, an HMG-box transcription factor expressed in gastric mucosa but not in intestine is thought to play an important role in regulating transcription and expression of gastric differentiation related genes. Herein, we investigated the possible role of SOX2 in MUC5AC transcription and in the development of mucinous cancers… CONTINUE READING
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